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Winona / Bettaway - Building the First Cosmeceutical Stock from Dermatological Clinical Endorsements

Founded: Guo Zhenyu · Yunnan Bettaway Biotechnology Group Co., Ltd.

JOURNEY

Key Fields

FIELD STAMPS
IndustryBeauty / Personal Care
RegionChina
ScaleGiant
ChannelOther

Origin

Guo Zhenyu previously worked at Dianhong Pharmaceutical managing Kangwang Shampoo, giving him a deep understanding of the clinical value of dermatologist prescriptions. After leaving Dianhong in 2010, he predicted that consumer demand for functional skincare would shift from conceptual marketing to clinically validated products. Leveraging Yunnan's rich plant resources (purslane, green thorn fruit), he partnered with Professor He Li's team at the First Affiliated Hospital of Kunming Medical University to validate products starting from dermatological clinics—pioneering a unique hospital-first, market-later route unlike any other cosmetics brand at the time.

Milestones

2010
Startup Turning Point
In 2010, after leaving Dianhong Pharmaceutical, Guo Zhenyu founded Bettaway in Yunnan. Partnering with local plant resources and Professor He Li's team at the First Affiliated Hospital of Kunming Medical University, he initiated the extraction and efficacy research of Yunnan-characteristic plant ingredients such as purslane and green thorn fruit. Initially starting with a team of less than 20 people and no proprietary factory, they relied on OEM production for their first batch of products, operating with limited capital and no established sales channels.
2011
Hospital Channel Validation PMF
Winona products entered the dermatology departments of dozens of tertiary grade-A hospitals nationwide, including the First Affiliated Hospital of Kunming Medical University, recommended as auxiliary skincare products. Professor He Li's team published multiple clinical observation papers confirming the repair effect of purslane extract on sensitive skin. During this period, the products bypassed the mass market, focusing entirely on clinical validation and accumulation through hospital channels, generating less than 100 million yuan in annual revenue with a team size under 50. This phase lasted from 2011 to 2013.
2014
Channel Expansion Failure
In 2014, Bettaway began expanding Winona from hospital channels into online e-commerce and offline counters. Early investments in the Tmall flagship store for brand education yielded extremely low conversion rates due to insufficient consumer awareness of the cosmeceutical concept. Online revenue in 2015 was approximately 200 million yuan, far below contemporary traditional cosmetics brands. Severe internal disagreements arose over whether to return to purely hospital channels, leading to the consecutive departures of two marketing directors and a temporary standstill in the online business.
2017
Online Explosion Turning Point
The topic of sensitive skin went viral on social media, and Winona scaled rapidly by leveraging dermatological endorsements and influencer seeding. Revenue reached approximately 350 million yuan in 2017, around 870 million yuan in 2018, and about 1.1 billion yuan in 2019, achieving a three-year compound growth rate exceeding 100%. However, excessive growth speed brought supply chain pressures. During the 2018 Singles' Day shopping festival, massive stockouts occurred, with multiple core single-products out of stock for over two months, causing them to miss the year-end sales peak with estimated losses exceeding 50 million yuan.
2020
Pandemic Catalyst Growth
Pandemic-derived skin issues such as maskne drove a surge in demand for sensitive skin care, significantly boosting sales at the Winona Tmall flagship store. Full-year 2020 revenue reached approximately 2.6 billion yuan, with net profit attributable to shareholders of around 540 million yuan and a gross margin of about 78%. However, vulnerabilities regarding over-reliance on online channels were fully exposed: online revenue accounted for over 82%, offline channel development severely lagged, and the number of nationwide offline counters stood at under 200.
2021
IPO Growth
On March 25, 2021, Bettaway was listed on the ChiNext board of the Shenzhen Stock Exchange with an issue price of 47.33 yuan per share and a first-day closing price around 155 yuan, up roughly 227%. Post-listing, its market capitalization briefly surpassed 160 billion yuan, earning it the title of the first cosmeceutical stock. However, the market quickly realized that its revenue derived almost entirely from the single Winona brand (accounting for over 97%), while a multi-brand matrix had yet to form. This structural risk triggered a stock price correction following the release of its first annual report after going public.
2022
Multi-Brand Dilemma Failure
Bettaway attempted a multi-brand strategy by launching new lines like Winona Baby for infants, but market reception was lukewarm. In 2022, Winona Baby revenue fell short of 100 million yuan, far below the internal target of 300 million yuan. Meanwhile, the flagship Winona brand faced siege from emerging competitors like Giant Biogene's Colglem and Forgez, which utilized medical-device-grade products and low-price strategies. Average order values in some online channels dropped by over 10%, causing Winona's Tmall beauty ranking to slip outside the top ten.
2024
Growth Bottleneck Turning Point
In 2024, competition in the functional skincare track became white-hot, as brands like Bloomage Biotech and Proya launched sensitive skin product lines, spreading price wars into the sub-100-yuan range. Bettaway's 2023 revenue reached around 5.5 billion yuan, with growth dropping from previous annual averages of around 40% to under 15%. The company attempted offline expansion by opening several independent stores, but monthly revenue for some stores was less than half of expectations, failing to prove a viable single-store model. The stock price fell more than 60% from its peak, erasing over 100 billion yuan in market value.
2026
Defending Barriers Turning Point
In July 2026, Bettaway's research and industrialization project for domestic functional skincare products won the Special Prize of the Yunnan Provincial Science and Technology Progress Award, making it the first beauty enterprise to receive this provincial-level special science award. Concurrently, the company advanced independent and controllable supply chain construction for Yunnan-characteristic plant ingredients, establishing raw material bases in regions like Haba Snow Mountain and applying for national regulatory filings for new raw materials. However, amidst escalating competition in functional skincare, transforming academic barriers into consumer-perceived brand differentiation remains the core challenge.

Turning Points

  • The 2011 decision to bypass the mass cosmetics route in favor of entering the dermatology departments of tertiary grade-A hospitals for clinical validation, utilizing academic papers and dermatologist prescriptions to build a brand trust barrier.
  • The 2014 pivot from pure hospital channels to online e-commerce. Despite early extremely low conversion rates and serious internal divisions, it ultimately leveraged the social media topic dividend for sensitive skin after 2017 to achieve explosive growth, tripling revenue in three years.
  • The post-IPO period in 2021 when market capitalization briefly topped 160 billion yuan, followed by the market's realization of single-brand reliance and failed multi-brand incubation, leading to a continuous stock price correction exceeding 60%.

Failures & Pitfalls

  • During the early online e-commerce phase from 2014 to 2016, consumer awareness of the cosmeceutical concept was low, leading to low conversion rates, consecutive departures of two marketing directors, and a temporary halt in online operations.
  • During the 2018 Singles' Day event, core blockbuster items were out of stock for over two months, exposing major shortcomings in supply chain management with estimated direct losses exceeding 50 million yuan.
  • In 2022, the multi-brand strategy stalled as Winona Baby generated under 100 million yuan, falling far short of the 300 million yuan target and failing to effectively diversify single-brand risk.
  • In 2024, during independent offline store expansion, monthly revenue for some stores failed to reach half of expectations, meaning the single-store model was unproven and offline channel investment was severely misaligned with output.

关键成功要素

  • Dermatological clinical validation serves as the foundation of the barrier; establishing brand marketing only after academic papers and hospital prescriptions ensures competitors cannot easily replicate this medical endorsement system in the short term.
  • Yunnan-characteristic plant ingredients (purslane, green thorn fruit, etc.) create raw material differentiation, while expanding upstream to cultivation bases achieves supply chain independence and control.
  • Explosive online growth relied on social media topic dividends within the niche sensitive skin segment; once track competition intensifies and traffic costs rise, growth immediately plateaus.
  • The structural risk of a single brand accounting for over 90% of revenue has never been resolved, and multi-brand incubation capability remains the greatest uncertainty for 2026 and the future.

Lessons

  • Medical endorsements are the most effective differentiation barriers for cosmeceutical brands, but the higher the barrier of a channel (hospitals), the lower its ceiling; knowing when to exit hospital channels and how to maintain academic tone are key decisions.
  • An excessively high proportion of online channels (over 80%) leads to high dependence on e-commerce platform traffic rules; once traffic dividends fade or platform policies change, revenue is directly impacted.
  • Multi-brand incubation requires forming genuine category segregation from the master brand; otherwise, new brands will be perceived by consumers as mere extensions of Winona rather than independent brands, making it difficult to tap incremental markets.
  • Competition in the functional skincare track lies not only in ingredient formulas, but also in supply chain efficiency and terminal pricing; if academic barriers are not converted into consumer-perceived price advantages, defensive protection is limited.

Core Data

  • 2020 revenue:Approx. 2.6 billion yuan (public data basis, independent verification unverified)
  • 2020 net profit attributable to shareholders:Approx. 540 million yuan (public data basis, independent verification unverified)
  • 2020 gross margin:Approx. 78% (public data basis, independent verification unverified)
  • 2021 revenue:Approx. 4 billion yuan (public data basis, independent verification unverified)
  • Peak market capitalization:Approx. 160 billion yuan (public data basis, independent verification unverified)
  • Winona brand revenue share:Over 97% (public data basis, independent verification unverified)
  • Online channel revenue share:Over 80% (public data basis, independent verification unverified)
  • 2023 revenue:Approx. 5.5 billion yuan (public data basis, independent verification unverified)
  • 2023 growth rate:Under 15% (public data basis, independent verification unverified)
  • Team size:Approx. 2,500 people (public data basis, independent verification unverified)
  • IPO issue price:47.33 yuan per share (public data basis, independent verification unverified)
  • First-day IPO surge:Approx. 227% (public data basis, independent verification unverified)

Competitors / Peers

Bettaway's major competitors in the functional skincare track include Giant Biogene's Colglem (centered on recombinant collagen, with 2023 revenue around 3.0 billion yuan and rapid growth), Forgez (starting from medical device masks, with 2022 revenue exceeding 1.8 billion yuan), Bloomage Biotech (the hyaluronic acid industry chain leader, with multi-brand functional skincare matrix annual revenue exceeding 6.0 billion yuan), Proya (a mass skincare giant with 2023 revenue exceeding 7.0 billion yuan, which launched the Power Series to enter the sensitive skin track), and international brands like L'Oréal's La Roche-Posay and SkinCeuticals. Among them, Giant Biogene and Forgez erode the sensitive skin market through low-pricing strategies and medical device registration endorsements, directly impacting Winona's pricing system, while international brands hold academic reputation and channel advantages in the high-end functional skincare market.